Chronic Heart Failure With Reduced Ejection Fraction| IONIS-AGT-LRx
A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Participants With Chronic Heart Failure With Reduced Ejection Fraction
This study will be a Phase 2, double-blind, randomized, placebo-controlled study in up to 72 participants. Participants will be randomized in a 2:1 ratio to either IONIS-AGT-LRX or matching placebo and receive a once-weekly SC treatment. The length of participation in the study will be approximately 29 weeks, which includes an up to 4-week screening period, a 12-week treatment period, and a 13-week post-treatment period.
Purpose of Study
The purpose of this study is to evaluate the effect of IONIS-AGT-LRX weekly subcutaneous (SC) injection on plasma angiotensinogen (AGT) concentration from Baseline to Study Day 85 (Week 13) and to evaluate the effect of IONIS-AGT-LRx weekly SC injection on plasma AGT concentration and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP) levels at each scheduled visit in chronic heart failure participants with reduced ejection fraction (HFrEF).
Age:18 - 80
Key Inclusion / Exclusion Criteria
- Females must be non-pregnant and non-lactating and of non-childbearing potential.
- Males must be surgically sterile or, abstinent or, if engaged in sexual relations with a woman of child-bearing potential (WOCBP), she must be willing to use a highly effective contraceptive method
- Screening NT-proBNP ≥ 600 picograms per milliliter (pg/mL) and less than (
- Established diagnosis of heart failure (HF) with reduced systolic function for at least 6 months prior to the screening visit (left ventricular ejection fraction, [LVEF] ≤ 40%
- New York Heart Association class I-III
- Participants should receive background standard of care for HFrEF. Therapy should have been individually optimized and stable for ≥ 4 weeks before randomization and include:
- An angiotensin-converting-enzyme inhibitor (ACEi), or angiotensin II receptor blockers (ARBs) or sacubitril/valsartan (mandatory)
- A beta-blocker (unless contraindicated or not tolerated)
- A mineralocorticoid receptor antagonist (MRA, unless contraindicated or not tolerated)
- Any cause of chronic HF other than ischemic cardiomyopathy and dilated cardiomyopathy
- Acute decompensated HF requiring intravenous (IV) diuretics, IV inotropes or IV vasodilators with discharge date within 30 days of screening or acute mechanical support (e.g., intra-aortic balloon pump, endotracheal intubation, mechanical ventilation, or any ventricular assist device) with discharge date within 90 days of screening.
- Symptomatic hypotension or systolic blood pressure (SBP) ≤ 90 millimeters of mercury (mmHg) at screening.
- Uncontrolled hypertension (HTN) (SBP > 160 mmHg or diastolic blood pressure (BP) > 100 mmHg) prior to screening.
- Heart transplant, and/or Left Ventricular Assist Device (LVAD) prior to screening or anticipated heart transplant or LVAD during the study.
- Implantation of a cardiac resynchronization therapy device (CRT) within 3 months prior screening or intent to implant a CRT within 3 months after screening.
- Acute coronary syndrome, unstable angina, stroke, transient ischemic attack (TIA), coronary revascularization, cardiac device implantation, cardiac valve repair, carotid or other major surgery within 3 months of screening.
- Coronary, valve or carotid artery disease likely to require surgical or percutaneous intervention within the 3 months after screening.
- Severe pulmonary disease with any of the following:
- Requirement of continuous (home) oxygen or
- Known diagnosis of severe chronic obstructive pulmonary disease (as defined by the American Thoracic Society/European Respiratory Society) or severe restrictive lung disease, in the opinion of the investigator.
- Screening laboratory results as follows, or any other clinically significant abnormalities in screening laboratory values that would render a participant unsuitable for inclusion in the opinion of the investigator.
- Alanine aminotransferase/aspartate aminotransferase (ALT/AST) > 2.0 × upper limit of normal (ULN).
- Total bilirubin ≥ 1.5 × ULN (participants with total bilirubin ≥ 1.5 × ULN may be allowed on study if indirect bilirubin only is elevated, ALT/AST is not greater than the ULN, and known to have Gilbert’s disease).
- Platelets < 100,000/millimeter^3 (mm^3).
- Urine protein creatinine ratio (UPCR) ≥ 500 milligrams per gram (mg/g).
- Hemoglobin A1c (HbA1c) > 9.5% or uncontrolled diabetes per investigator judgement.
- Estimated glomerular filtration rate (eGFR) < 40 milliliters/minute /1.73 m^2 (mL/min/1.73 meter^2) at screening.
- Abnormal thyroid function tests with clinical significance per investigator judgement.
- Serum potassium > 4.7 millimoles per liter (mmol/L) at screening.
- Requirement of treatment with both ACEi and ARBs.
- Previous history of intolerance to ACEi or ARBs or history of hyperkalemia.
Chronic Heart Failure With Reduced Ejection Fraction
Clinical Trials ID
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Start Date / End Date:
06 2021 - 09 2022
12 Study Locations
The Lindner Center for Research and Education at The Christ Hospital
Cincinnati, Ohio, 45219